{"id":36794,"date":"2024-01-14T04:03:17","date_gmt":"2024-01-14T04:03:17","guid":{"rendered":"https:\/\/science-hub.click\/%E3%83%A9%E3%83%9F%E3%83%96%E3%82%B8%E3%83%B3%E3%81%AB%E3%81%A4%E3%81%84%E3%81%A6%E8%A9%B3%E3%81%97%E3%81%8F%E8%A7%A3%E8%AA%AC\/"},"modified":"2024-01-14T04:03:17","modified_gmt":"2024-01-14T04:03:17","slug":"%E3%83%A9%E3%83%9F%E3%83%96%E3%82%B8%E3%83%B3%E3%81%AB%E3%81%A4%E3%81%84%E3%81%A6%E8%A9%B3%E3%81%97%E3%81%8F%E8%A7%A3%E8%AA%AC","status":"publish","type":"post","link":"https:\/\/science-hub.click\/?p=36794","title":{"rendered":"\u30e9\u30df\u30d6\u30b8\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac"},"content":{"rendered":"

\u5c0e\u5165<\/h2>
\u30e9\u30df\u30d6\u30b8\u30f3<\/th><\/tr>
\n\"\u30e9\u30df\u30d6\u30b8\u30f3\"<\/figure><\/td><\/tr>
\u4e00\u822c\u7684\u306a<\/th><\/tr>
IUPAC\u540d<\/td><\/tr>
\u540c\u7fa9\u8a9e<\/td>3TC<\/td><\/tr>
CAS\u756a\u53f7<\/sup><\/td>134678-17-4<\/span><\/span> (2 R<\/i> .5 S<\/i> ) (-)<\/td><\/tr>
ATC\u30b3\u30fc\u30c9<\/td>J05<\/span><\/span> AF05<\/span><\/span><\/td><\/tr>
\u30c9\u30e9\u30c3\u30b0\u30d0\u30f3\u30af<\/td>APRD00681<\/span><\/td><\/tr>
\u30d1\u30d6\u30b1\u30e0<\/td>60825<\/span><\/td><\/tr>
\u5316\u5b66\u7684\u6027\u8cea<\/th><\/tr>
\u751f\u306e\u30d5\u30a9\u30fc\u30df\u30e5\u30e9<\/td>C8H11N3O3S<\/sub>\u200b<\/sub>\u200b<\/sub>\u200b<\/sub><\/td><\/tr>
\u30e2\u30eb\u8cea\u91cf<\/a><\/span><\/td>229.256 \u00b1 0.014 g\u30fbmol -1<\/sup><\/td><\/tr>
\u85ac\u7269\u52d5\u614b\u30c7\u30fc\u30bf<\/a><\/span><\/th><\/tr>
\u30d0\u30a4\u30aa\u30a2\u30d9\u30a4\u30e9\u30d3\u30ea\u30c6\u30a3<\/td>86%<\/td><\/tr>
\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7d50\u5408<\/td>36%\u672a\u6e80<\/td><\/tr>
\u4ee3\u8b1d<\/a><\/span><\/td>\u814e\u81d3 (\u7d04 70% \u304c\u5909\u5316\u305b\u305a\u306b\u56de\u5fa9\u3002\u4e3b\u306a\u4ee3\u8b1d\u7523\u7269\u306f S-\u30aa\u30ad\u30b7\u30c1\u30a2\u30b7\u30c1\u30b8\u30f3)<\/td><\/tr>
\u9664\u53bb\u534a\u6e1b\u671f<\/a><\/span><\/td>\u5348\u524d5\u6642\u304b\u30897\u6642\u307e\u3067<\/td><\/tr>
\u6392\u6cc4<\/td>\u5c3f\u8def<\/td><\/tr>
\u6cbb\u7642\u4e0a\u306e\u8003\u616e\u4e8b\u9805<\/th><\/tr>
\u6295\u4e0e\u7d4c\u8def<\/td>\u7d4c\u53e3\u3001IV<\/td><\/tr>
\u7279\u306b\u6307\u5b9a\u306e<\/a><\/span>\u306a\u3044\u9650\u308a\u3001SI \u304a\u3088\u3073 CNTP \u5358\u4f4d\u3002<\/center><\/td><\/tr><\/table>

\u30e9\u30df\u30d6\u30b8\u30f3<\/b>(2′,3′-\u30b8\u30c7\u30aa\u30ad\u30b7-3′-\u30c1\u30a2\u30b7\u30c1\u30b8\u30f3\u3001 3TC<\/b> ) \u306f\u3001Epivir<\/b>\u3068\u3044\u3046\u540d\u524d\u3067\u8ca9\u58f2\u3055\u308c\u3066\u3044\u308b\u5f37\u529b\u306a\u9006<\/a><\/span>\u8ee2\u5199\u9175\u7d20\u963b\u5bb3\u5264\u3067\u3059\u3002\u3053\u308c\u306f\u3001HIV \u9006\u8ee2\u5199\u9175\u7d20\u306e\u4e21\u65b9\u306e\u30bf\u30a4\u30d7 (1 \u304a\u3088\u3073 2) \u3068B \u578b\u809d\u708e<\/a><\/span>\u30a6\u30a4\u30eb\u30b9<\/a><\/span>\u306e\u9006\u8ee2\u5199\u9175\u7d20\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002\u6d3b\u6027\u5316\u3059\u308b\u306b\u306f\u3001\u4e09\u30ea\u30f3\u9178\u306e\u5f62\u3067\u30ea\u30f3\u9178\u5316\u3055\u308c\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u30013TC \u4e09\u30ea\u30f3\u9178\u306f\u7d30\u80de\u306e DNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u3092<\/a><\/span>\u963b\u5bb3\u3057\u307e\u3059\u3002\u73fe\u5728\u6700\u3082\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u6297\u30ec\u30c8\u30ed\u30a6\u30a4\u30eb\u30b9<\/a><\/span>\u85ac<\/a><\/span>\u3067\u3042\u308a\u3001\u30a8\u30a4\u30ba\u306b\u3088\u308b\u6b7b\u4ea1\u7387\u304c\u5927\u5e45\u306b\u4f4e\u4e0b\u3057\u305f1995\u5e74\u304b\u30891996\u5e74\u306b\u4e09\u5264\u4f75\u7528\u7642\u6cd5<\/a><\/span>\u304c\u5c0e\u5165\u3055\u308c\u3066\u4ee5\u6765\u3001\u307b\u307c\u4f53\u7cfb\u7684\u306b\u51e6\u65b9\u3055\u308c\u3066\u3044\u308b\u3002<\/p>

\u30e9\u30df\u30d6\u30b8\u30f3\u306f\u7d4c\u53e3\u6295\u4e0e\u3055\u308c\u300180\uff05\u3092\u8d85\u3048\u308b\u751f\u7269\u5b66\u7684\u5229\u7528\u7387\u3067\u6025\u901f\u306b\u5438\u53ce\u3055\u308c\u307e\u3059\u3002\u3055\u307e\u3056\u307e\u306a\u7814\u7a76\u306f\u3001\u30e9\u30df\u30d6\u30b8\u30f3\u304c\u8840\u6db2\u8133\u95a2\u9580<\/a><\/span>\u3092\u901a\u904e<\/a><\/span>\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3059\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u30b8\u30c9\u30d6\u30b8\u30f3<\/a><\/span>\u3068\u7d44\u307f\u5408\u308f\u305b<\/span>\u3066\u4f7f\u7528\u200b\u200b\u3055\u308c\u308b\u3053\u3068\u304c\u3088\u304f\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089 2 \u3064\u306e\u6297\u30ec\u30c8\u30ed\u30a6\u30a4\u30eb\u30b9\u85ac\u306f\u76f8\u4e57\u7684\u306b\u4f5c\u7528\u3057\u307e\u3059\u3002\u30e9\u30df\u30d6\u30b8\u30f3\u306b\u3088\u308b\u6cbb\u7642\u306f\u3001HIV \u306b\u5bfe\u3057\u3066\u8010\u6027\u306b\u306a\u3063\u305f\u4eba\u3005\u306e\u30b8\u30c9\u30d6\u30b8\u30f3\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u3092\u56de\u5fa9\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>

HIV \u306e\u7a81\u7136\u5909\u7570 (M184V) \u306b\u3088\u308a\u3001HIV \u306f\u30e9\u30df\u30d6\u30b8\u30f3\u306b\u5bfe\u3059\u308b\u8010\u6027\u3092\u7372\u5f97\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u4e00\u822c\u306b\u3001\u305f\u3068\u3048\u3053\u306e\u3088\u3046\u306a\u5909\u7570\u304c\u8d77\u3053\u3063\u305f\u3068\u3057\u3066\u3082\u30013TC\u306b\u3088\u308b\u6cbb\u7642\u3092\u7d99\u7d9a\u3059\u308b\u3053\u3068\u304c\u8ce2\u660e\u3067\u3059\u3002\u3053\u306e\u5909\u7570\u306b\u3088\u308a\u3001\u8907\u88fd\u52b9\u7387\u304c\u4f4e\u4e0b\u3057\u3001\u4f9d\u7136\u3068\u3057\u3066\u30e9\u30df\u30d6\u30b8\u30f3\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u305f\u307e\u307e\u306e\u30a6\u30a4\u30eb\u30b9\u304c\u751f\u6210\u3055\u308c\u308b\u3088\u3046\u3067\u3059\u3002\u4f8b\u3048\u3070\u3001\u30a6\u30a4\u30eb\u30b9\u304c\u30e9\u30df\u30d6\u30b8\u30f3\u306b\u8010\u6027\u3068\u306a\u3063\u305f3\u5264\u4f75\u7528\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u305fHIV\u967d\u6027\u60a3\u8005\u306b\u304a\u3044\u3066\u306f\u30013TC\u5358\u72ec\u7642\u6cd5\u306e\u65b9\u304c\u6cbb\u7642\u3092<\/a><\/span>\u4e2d\u6b62\u3059\u308b\u3088\u308a\u3082\u81e8\u5e8a\u7684\u304a\u3088\u3073\u514d\u75ab\u5b66\u7684\u8ee2\u5e30\u304c\u826f\u597d\u3067\u3042\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u308b\u3002 3 \u5264\u4f75\u7528\u7642\u6cd5\u306e\u5834\u5408\u3001\u4ed6\u306e\u5909\u7570\u304c\u89b3\u5bdf\u3055\u308c\u306a\u3051\u308c\u3070\u3001\u5909\u7570\u30a6\u30a4\u30eb\u30b9\u306f\u4ed6\u306e\u5206\u5b50\u306b\u5bfe\u3057\u3066\u611f\u53d7\u6027\u3092\u4fdd\u3061\u307e\u3059\u3002\u591a\u304f\u306e\u5909\u7570\u539f\u6027\u8a66\u9a13\u306b\u3088\u308a\u3001\u30e9\u30df\u30d6\u30b8\u30f3\u306f\u6cbb\u7642\u7528\u91cf\u3067\u306f\u5909\u7570\u539f\u6027\u6d3b\u6027\u3092<\/a><\/span>\u793a\u3055\u306a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>

\u30e9\u30df\u30d6\u30b8\u30f3\u306f\u3001HIV \u611f\u67d3\u75c7\u306e\u6cbb\u7642\u306b\u4f7f\u7528\u3055\u308c\u308b\u3088\u308a\u3082\u4f4e\u7528\u91cf\u3067\u6162\u6027 B \u578b\u809d\u708e<\/a><\/span>\u306e\u6cbb\u7642\u306b\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002 B\u578b\u809d\u708e\u6297\u539f<\/a><\/span>\u967d\u6027\u306e\u8840\u6e05\u5909\u63db\u3092\u6539\u5584\u3057\u3001\u809d\u81d3\u306e<\/a><\/span>\u7d44\u7e54\u5b66\u7684\u75c5\u671f<\/a><\/span>\u5206\u985e\u3082\u6539\u5584\u3057\u307e\u3059\u3002\u6b8b\u5ff5\u306a\u3053\u3068\u306b\u3001\u30e9\u30df\u30d6\u30b8\u30f3\u306e\u9577\u671f\u4f7f\u7528\u306f\u3001\u7a81\u7136\u5909\u7570\u306b\u3088\u308b\u8010\u6027 B \u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9 (YMDD) \u306e\u767a\u751f\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002\u305d\u308c\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u30e9\u30df\u30d6\u30b8\u30f3\u306f\u5fcd\u5bb9\u6027\u304c\u9ad8\u3044\u305f\u3081\u3001\u4f9d\u7136\u3068\u3057\u3066\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p><\/div>

\n\"\u30e9\u30df\u30d6\u30b8\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\"<\/figure>

\u53c2\u8003\u8cc7\u6599<\/h2>
  1. Lamivudien \u2013 afrikaans<\/a><\/li>
  2. \u0644\u0627\u0645\u064a\u0641\u0648\u062f\u064a\u0646 \u2013 arabe<\/a><\/li>
  3. Lamifwdin \u2013 gallois<\/a><\/li>
  4. Lamivudin \u2013 allemand<\/a><\/li>
  5. Lamivudine \u2013 anglais<\/a><\/li>
  6. Lamivudina \u2013 espagnol<\/a><\/li><\/ol><\/div>\n
    \n

    \n \u30e9\u30df\u30d6\u30b8\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u30fb\u95a2\u9023\u52d5\u753b\n <\/h2>\n
    \n \n
    \n
    \n