{"id":41274,"date":"2024-03-15T17:18:58","date_gmt":"2024-03-15T17:18:58","guid":{"rendered":"https:\/\/science-hub.click\/%E3%83%96%E3%83%97%E3%83%AD%E3%83%94%E3%82%AA%E3%83%B3%E3%81%AB%E3%81%A4%E3%81%84%E3%81%A6%E8%A9%B3%E3%81%97%E3%81%8F%E8%A7%A3%E8%AA%AC\/"},"modified":"2024-03-15T17:18:58","modified_gmt":"2024-03-15T17:18:58","slug":"%E3%83%96%E3%83%97%E3%83%AD%E3%83%94%E3%82%AA%E3%83%B3%E3%81%AB%E3%81%A4%E3%81%84%E3%81%A6%E8%A9%B3%E3%81%97%E3%81%8F%E8%A7%A3%E8%AA%AC","status":"publish","type":"post","link":"https:\/\/science-hub.click\/?p=41274","title":{"rendered":"\u30d6\u30d7\u30ed\u30d4\u30aa\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac"},"content":{"rendered":"

\u5c0e\u5165<\/h2>
\u30d6\u30d7\u30ed\u30d4\u30aa\u30f3<\/th><\/tr>
\n\"\u30d6\u30d7\u30ed\u30d4\u30aa\u30f3\u306e<\/figure><\/td><\/tr>
\u4e00\u822c\u7684\u306a<\/th><\/tr>
IUPAC\u540d<\/td><\/tr>
CAS\u756a\u53f7<\/sup><\/td>34911-55-2<\/span><\/span> (\u30e9\u30bb\u30df) 144445-75-0<\/span><\/span> (+) 144445-76-1<\/span><\/span> (-)<\/td><\/tr>
ATC\u30b3\u30fc\u30c9<\/td>N06<\/span> AX12<\/span><\/span><\/td><\/tr>
\u30c9\u30e9\u30c3\u30b0\u30d0\u30f3\u30af<\/td>DB01156<\/span><\/td><\/tr>
\u30d1\u30d6\u30b1\u30e0<\/td>444<\/span><\/td><\/tr>
\u7b11\u9854<\/td><\/tr>
\u30a4\u30f3\u30c1\u30c1<\/td><\/tr>
\u5316\u5b66\u7684\u6027\u8cea<\/th><\/tr>
\u751f\u306e\u30d5\u30a9\u30fc\u30df\u30e5\u30e9<\/td>C13H18ClNO<\/sub>\u200b<\/sub><\/td><\/tr>
\u30e2\u30eb\u8cea\u91cf<\/a><\/span><\/td>239.741 \u00b1 0.014 g mol -1<\/sup><\/td><\/tr>
pKa<\/td> 7.9<\/td><\/tr>
\u7269\u7406\u7684\u6027\u8cea<\/th><\/tr>
\u878d\u89e3<\/a><\/span>\u6e29\u5ea6<\/td>233<\/span> \uff5e 234<\/span> \u2103<\/abbr><\/td><\/tr>
\u5bc6\u5ea6<\/a><\/span><\/td>1.066g<\/span> cm<\/span> -3<\/sup>\u200b<\/span><\/span><\/td><\/tr>
\u98fd\u548c\u84b8\u6c17\u5727<\/a><\/span><\/td>0.000125<\/span> mmHg<\/span><\/span> ( 25<\/span> \u00b0C<\/abbr> )<\/td><\/tr>
\u4e88\u9632<\/th><\/tr>
\u6307\u4ee4 67\/548\/EEC <\/center><\/td><\/tr>
\n\"\u6709\u5bb3\"<\/figure> Xn<\/center><\/td><\/tr><\/table><\/td><\/tr>
R\u30d5\u30ec\u30fc\u30ba\uff1a 22\u3001<\/span><\/td><\/tr>
S\u30d5\u30ec\u30fc\u30ba\uff1a 36\u3001<\/span><\/td><\/tr>
\u751f\u614b\u6bd2\u6027\u5b66<\/th><\/tr>
DL<\/td> 544<\/span> mg<\/span>\u30fbkg<\/span> -1<\/sup><\/span> (\u30de\u30a6\u30b9\u3001\u7d4c\u53e3)<\/td><\/tr>
\u85ac\u7269\u52d5\u614b\u30c7\u30fc\u30bf<\/a><\/span><\/th><\/tr>
\u30d0\u30a4\u30aa\u30a2\u30d9\u30a4\u30e9\u30d3\u30ea\u30c6\u30a3<\/td>\u52d5\u7269\u3067\u306f5\uff5e20%\u3002\u4eba\u9593<\/a><\/span>\u3067\u306e\u7814\u7a76\u306f\u3042\u308a\u307e\u305b\u3093<\/td><\/tr>
\u4ee3\u8b1d<\/a><\/span><\/td>\u809d\u81d3\u3001 CYP2B6<\/span>\u304a\u3088\u3073 CYP2D6 \u9175\u7d20\u304c\u5927\u304d\u304f\u95a2\u4e0e<\/td><\/tr>
\u9664\u53bb\u534a\u6e1b\u671f<\/a><\/span><\/td>\u5348\u5f8c<\/a><\/span>8\u6642<\/td><\/tr>
\u6392\u6cc4<\/td>\u814e\u81d3 (87%)\u3001\u7cde\u4fbf (10%)<\/td><\/tr>
\u6cbb\u7642\u4e0a\u306e\u8003\u616e\u4e8b\u9805<\/th><\/tr>
\u6295\u4e0e\u7d4c\u8def<\/td>\u30aa\u30fc\u30e9\u30eb<\/td><\/tr>
\u7279\u306b\u6307\u5b9a\u306e<\/a><\/span>\u306a\u3044\u9650\u308a\u3001SI \u304a\u3088\u3073 CNTP \u5358\u4f4d\u3002<\/center><\/td><\/tr><\/table>

\u30d6\u30d7\u30ed\u30d4\u30aa\u30f3\u306f<\/b>\u3001\u30b0\u30e9\u30af\u30bd\u30fb\u30b9\u30df\u30b9\u30af\u30e9\u30a4\u30f3\u7814\u7a76\u6240\u306b\u3088\u3063\u3066\u30b6\u30a4\u30d0\u30f3<\/b>\u304a\u3088\u3073\u30a6\u30a7\u30eb\u30d6\u30c8\u30ea\u30f3\u306e<\/b>\u30d6\u30e9\u30f3\u30c9\u540d\u3067\u8ca9\u58f2\u3055\u308c\u3066\u304a\u308a\u3001\u7981\u7159\u306e\u88dc\u52a9\u3068\u3057\u3066\u51e6\u65b9\u3055\u308c\u308b\u85ac<\/a><\/span>\u3067\u3059\u3002\u30b5\u30dd\u30fc\u30c8\u3068\u5fc3\u7406\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3092\u4f34\u3044\u30012001 \u5e74 8 \u6708\u306b\u30d5\u30e9\u30f3\u30b9\u3067\u8ca9\u58f2<\/a><\/span>\u627f\u8a8d\u3092\u53d6\u5f97\u3057\u307e\u3057\u305f\u3002<\/p>

DCI \u540d\u300c\u30d6\u30d7\u30ed\u30d4\u30aa\u30f3\u300d\u306f\u3001\u6700\u521d\u306e DCI \u540d\u306b\u4ee3\u308f\u3063\u3066 2000 \u5e74\u306b\u767b\u5834\u3057\u307e\u3057\u305f\u3002\u5b9f\u969b\u3001\u305d\u306e\u5206\u5b50\u304c<\/a><\/span>\u30a2\u30f3\u30d5\u30a7\u30bf\u30df\u30f3<\/a><\/span>\u304a\u3088\u3073\u30a2\u30f3\u30d5\u30a7\u30d7\u30e9\u30e2\u30f3\uff08\u30b8\u30a8\u30c1\u30eb\u30d7\u30ed\u30d4\u30aa\u30f3\uff09\u306b\u975e\u5e38\u306b\u8fd1\u3044\u305f\u3081\u3001\u5143\u306e INN \u540d\u306f\u300c\u30a2\u30f3\u30d5\u30a7\u30d6\u30bf\u30e2\u30f3\u300d\u3067\u3059\u3002<\/p>

\n\"\u30d6\u30d7\u30ed\u30d4\u30aa\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\"<\/figure>

\u7981\u7159\u3092\u52a9\u3051\u308b\u52b9\u679c<\/h2>

2006\u5e74\u306b\u767a\u8868\u3055\u308c\u305f\u4e3b\u8981\u306a\u7814\u7a76\u3067\u306f\u3001\u7981\u7159\u306b\u5f79\u7acb\u30642\u3064\u306e\u5206\u5b50\u3001\u30d0\u30ec\u30cb\u30af\u30ea\u30f3\uff08\u30c1\u30e3\u30f3\u30d4\u30c3\u30af\u30b9\uff09\u3068\u30d6\u30d7\u30ed\u30d4\u30aa\u30f3\uff08\u30b6\u30a4\u30d0\u30f3\uff09\u306e\u7d50\u679c\u3068\u30d7\u30e9\u30bb\u30dc\u306e\u7d50\u679c\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002 12\u304b\u6708<\/a><\/span>\u5f8c\u306e\u7981\u7159<\/a><\/span>\u7387\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306710%\u3001\u30d6\u30d7\u30ed\u30d4\u30aa\u30f3\u7fa4\u306715%\u3001\u30d0\u30ec\u30cb\u30af\u30ea\u30f3\u7fa4\u306723%\u3067\u3057\u305f\u3002<\/p>

\u5b9f\u7528\u7684\u306a\u60c5\u5831<\/h2>

\u51e6\u65b9\u7b8b\u306b\u3088\u3063\u3066\u306e\u307f\u5165\u624b\u53ef\u80fd\u3067\u3059\u3002<\/p>

\u9069\u5fdc\u75c7<\/h2>

\u30d6\u30d7\u30ed\u30d4\u30aa\u30f3\u306f\u3001\u30bf\u30d0\u30b3\u306e\u4f7f\u7528\u4e2d\u306b\u5438\u53ce\u3055\u308c\u308b\u30cb\u30b3\u30c1\u30f3<\/a><\/span>\u306b\u4f9d\u5b58\u3057\u3066\u3044\u308b\u4eba\u3005\u306e\u6cbb\u7642\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002\u305d\u306e\u30c9\u30fc\u30d1\u30df\u30f3\u4f5c\u52d5\u6027\u4f5c\u7528\uff08\u3053\u308c\u304c\u552f\u4e00\u306e\u4f5c\u7528\u3067\u306f\u3042\u308a\u307e\u305b\u3093\uff09\u306f\u3001\u55ab\u7159\u8005\u304c\u30cb\u30b3\u30c1\u30f3\u306e\u6442\u53d6\u3092\u907f\u3051\u308b\u3053\u3068<\/a><\/span>\u3092\u53ef\u80fd\u306b\u3059\u308b\u5831\u916c\u56de\u8def\u306b\u304a\u3044\u3066\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u30bb\u30ed\u30c8\u30cb\u30f3\u4f5c\u52d5\u6027\u304a\u3088\u3073\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u4f5c\u52d5\u6027\u56de\u8def\u3078\u306e\u4f5c\u7528\u306b\u3088\u308a\u3001\u3053\u306e\u5206\u5b50\u306b\u6297\u3046\u3064<\/a><\/span>\u52b9\u679c\u304c\u52a0\u308f\u308a\u3001\u96e2\u8131\u4e2d\u306b\u975e\u5e38\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>

\u526f\u4f5c\u7528<\/h2>

\u30d6\u30d7\u30ed\u30d4\u30aa\u30f3\u306e\u526f\u4f5c\u7528\u306f\u6570\u591a\u304f\u3042\u308a\u3001\u591a\u304b\u308c\u5c11\u306a\u304b\u308c\u4e00\u822c\u7684\u3067\u3059\u3002\u6700\u3082\u4e00\u822c\u7684\u306a\u3082\u306e\u306f\u3001\u6d88\u5316\u5668\u75be\u60a3\uff08\u53e3\u6e07\u3001\u5410\u304d\u6c17\u3068\u5614\u5410\u3001\u8179\u75db<\/a><\/span>\u3001\u4fbf\u79d8<\/a><\/span>\u306a\u3069\uff09\u3001\u795e\u7d4c\u75be\u60a3\uff08\u4e0d\u7720\u75c7\u3001\u982d\u75db\u3001\u4e0d\u5b89\u306a\u3069\uff09\u3001\u5fc3\u81d3\u8840\u7ba1\u75be\u60a3\uff08\u4e0d\u6574\u8108\u3001\u8840\u5727<\/a><\/span>\uff09\u3001\u307e\u305f\u306f\u76ae\u819a\uff08\u767a\u75b9\u3001\u304b\u3086\u307f\uff09\u3067\u3059\u3002 \u3001\u767a\u6c57\u306a\u3069\uff09\u3002<\/p>

\u884c\u52d5\u69d8\u5f0f<\/h2>

\u30d6\u30d7\u30ed\u30d4\u30aa\u30f3\u306f\u3001\u30ab\u30c6\u30b3\u30fc\u30eb\u30a2\u30df\u30f3\u306e\u795e\u7d4c\u7d30\u80de\u3078\u306e\u518d\u53d6\u308a\u8fbc\u307f\u306e\u9078\u629e\u7684\u963b\u5bb3\u5264\u3067\u3042\u308a\u3001\u6297\u3046\u3064\u85ac\u30bf\u30a4\u30d7\u306e\u5411\u7cbe\u795e\u85ac<\/a><\/span>\u3068\u306a\u308a\u307e\u3059\u3002\u4f5c\u7528\u6a5f\u5e8f\u306f\u30c9\u30fc\u30d1\u30df\u30f3<\/a><\/span>\u3068\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u306e\u30ec\u30d9\u30eb\u306b\u57fa\u3065\u3044\u3066\u3044\u308b\u3088\u3046\u3067\u3059<\/p><\/div>

\u53c2\u8003\u8cc7\u6599<\/h2>
  1. \u0628\u0648\u0628\u0631\u0648\u0628\u064a\u0648\u0646 \u2013 arabe<\/a><\/li>
  2. \u0628\u0648\u067e\u0631\u0648\u067e\u06cc\u0648\u0646 \u2013 South Azerbaijani<\/a><\/li>
  3. Bupropi\u00f3 \u2013 catalan<\/a><\/li>
  4. Bupropion \u2013 tch\u00e8que<\/a><\/li>
  5. Bwpropion \u2013 gallois<\/a><\/li>
  6. Bupropion \u2013 danois<\/a><\/li><\/ol><\/div>\n
    \n

    \n \u30d6\u30d7\u30ed\u30d4\u30aa\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u30fb\u95a2\u9023\u52d5\u753b\n <\/h2>\n
    \n \n
    \n
    \n