{"id":55969,"date":"2024-02-07T01:54:54","date_gmt":"2024-02-07T01:54:54","guid":{"rendered":"https:\/\/science-hub.click\/%E3%82%B7%E3%83%AB%E3%83%87%E3%83%8A%E3%83%95%E3%82%A3%E3%83%AB%E3%81%AB%E3%81%A4%E3%81%84%E3%81%A6%E8%A9%B3%E3%81%97%E3%81%8F%E8%A7%A3%E8%AA%AC\/"},"modified":"2024-02-07T01:54:54","modified_gmt":"2024-02-07T01:54:54","slug":"%E3%82%B7%E3%83%AB%E3%83%87%E3%83%8A%E3%83%95%E3%82%A3%E3%83%AB%E3%81%AB%E3%81%A4%E3%81%84%E3%81%A6%E8%A9%B3%E3%81%97%E3%81%8F%E8%A7%A3%E8%AA%AC","status":"publish","type":"post","link":"https:\/\/science-hub.click\/?p=55969","title":{"rendered":"\u30b7\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac"},"content":{"rendered":"

\u5c0e\u5165<\/h2>
\u30b7\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb<\/th><\/tr>
\n\"\u30b7\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\"<\/figure>
\n\"\u30b7\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\"<\/figure><\/td><\/tr>
\u4e00\u822c\u7684\u306a<\/th><\/tr>
IUPAC\u540d<\/td><\/tr>
CAS\u756a\u53f7<\/sup><\/td>139755-83-2<\/span><\/span> 171599-83-0<\/span><\/span> (\u30af\u30a8\u30f3\u9178\u5869)<\/td><\/tr>
ATC\u30b3\u30fc\u30c9<\/td>G04<\/span><\/span> BE03<\/span><\/span><\/td><\/tr>
\u30c9\u30e9\u30c3\u30b0\u30d0\u30f3\u30af<\/td>APRD00556<\/span><\/td><\/tr>
\u30d1\u30d6\u30b1\u30e0<\/td>5281023<\/span><\/td><\/tr>
\u7b11\u9854<\/td><\/tr>
\u30a4\u30f3\u30c1\u30c1<\/td><\/tr>
\u5916\u89b3<\/td>\u56fa\u4f53<\/td><\/tr>
\u5316\u5b66\u7684\u6027\u8cea<\/th><\/tr>
\u751f\u306e\u30d5\u30a9\u30fc\u30df\u30e5\u30e9<\/td>C 22<\/sub> H 30<\/sub> N 6<\/sub> W 4<\/sub> S<\/td><\/tr>
\u30e2\u30eb\u8cea\u91cf<\/a><\/span><\/td>474.576 \u00b1 0.027 g mol -1<\/sup><\/td><\/tr>
\u7269\u7406\u7684\u6027\u8cea<\/th><\/tr>
\u878d\u89e3<\/a><\/span>\u6e29\u5ea6<\/td>189<\/span> \uff5e 190<\/span> \u2103<\/span><\/span><\/td><\/tr>
\u85ac\u7269\u52d5\u614b\u30c7\u30fc\u30bf<\/a><\/span><\/th><\/tr>
\u30d0\u30a4\u30aa\u30a2\u30d9\u30a4\u30e9\u30d3\u30ea\u30c6\u30a3<\/td>40%<\/td><\/tr>
\u4ee3\u8b1d<\/a><\/span><\/td>\u809d\u81d3\u306eCYP3A4\uff08\u30e1\u30b8\u30e3\u30fc\uff09\u304a\u3088\u3073CYP2C9\uff08\u30de\u30a4\u30ca\u30fc\uff09<\/td><\/tr>
\u5206\u5e03\u534a\u6e1b\u671f<\/a><\/span><\/td>
  • \u6700\u5927\u6fc3\u5ea6\uff1a60\u5206<\/span>\uff08\u7bc4\u56f2\uff1d30\u5206\uff5e120\u5206\uff09<\/li>
  • \u98df\u54c1: \u8102\u80aa\u5206\u306e\u591a\u3044\u98df\u4e8b\u306f\u6700\u5927\u6fc3\u5ea6\u3092 29% \u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002<\/li><\/ul>
    1. 65\u6b73\u4ee5\u4e0a\u306e\u4eba\uff1a\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u306e\u6e1b\u5c11<\/li>
    2. \u91cd\u5ea6\u306e\u814e\u4e0d\u5168 (\u63a8\u5b9a ClCR > 30mL\/min): \u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u306e\u4f4e\u4e0b<\/li><\/ol><\/td><\/tr>
\u6392\u6cc4<\/td>
  • \u7cde\u4fbf: 80% \u306f\u4ee3\u8b1d\u7523\u7269\u306e\u5f62\u3067\u3059\u3002<\/li>
  • \u814e\u81d3: 13% \u304c\u4ee3\u8b1d\u7523\u7269\u306e\u5f62\u3002<\/li>
  • \u900f\u6790\u4e0d\u53ef\u3002<\/li><\/ul><\/td><\/tr>
\u6cbb\u7642\u4e0a\u306e\u8003\u616e\u4e8b\u9805<\/th><\/tr>
\u6295\u4e0e\u7d4c\u8def<\/td>\u30aa\u30fc\u30e9\u30eb<\/td><\/tr>
\u7279\u306b\u6307\u5b9a\u306e<\/a><\/span>\u306a\u3044\u9650\u308a\u3001SI \u304a\u3088\u3073 CNTP \u5358\u4f4d\u3002<\/center><\/td><\/tr><\/table>
\n\"\"<\/figure>
\u30d0\u30a4\u30a2\u30b0\u30e9<\/div><\/div><\/div>

\u30af\u30a8\u30f3\u9178\u30b7\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb<\/b>\uff08\u56fd\u969b\u4e00\u822c\u540d\uff09\u306f\u3001\u88fd\u85ac\u4f1a\u793e\u30d5\u30a1\u30a4\u30b6\u30fc\u306b\u3088\u308a\u30d0\u30a4\u30a2\u30b0\u30e9<\/b>\u00ae \u30d6\u30e9\u30f3\u30c9\u3067\u958b\u767a\u3055\u308c\u305f\u30db\u30b9\u30db\u30b8\u30a8\u30b9\u30c6\u30e9\u30fc\u30bc 5 \u578b\u963b\u5bb3\u5264\u306e\u30af\u30e9\u30b9\u306e\u85ac\u5264<\/a><\/span>\u3067\u3059\u3002\u3053\u306e\u85ac\u306f\u6027\u7684\u30a4\u30f3\u30dd\u30c6\u30f3\u30b9<\/a><\/span>\u304a\u3088\u3073\u80ba\u52d5\u8108\u6027\u80ba\u9ad8\u8840\u5727\u75c7<\/a><\/span>\u306b\u9069\u5fdc\u3055\u308c\u3066\u3044\u307e\u3059 ( Revatio\u00ae<\/b> )\u3002<\/p>

\u6b74\u53f2<\/h2>

1978\u5e74\u3001\u30ed\u30d0\u30fc\u30c8\u30fb\u30d5\u30a1\u30fc\u30c1\u30b4\u30c3\u30c8\u306f<\/a><\/span>\u8840\u7ba1\u3092\u5f1b\u7de9\u3055\u305b\u308b\u5185\u76ae\u7d30\u80de\u5185\u306e\u7269\u8cea\u3092\u767a\u898b\u3057\u3001\u3053\u308c\u3092\u5185\u76ae\u7531\u6765\u5f1b\u7de9\u56e0\u5b50\uff08EDRF\uff09\u3068\u540d\u4ed8\u3051\u305f\u3002 1986 \u5e74\u307e\u3067\u306b\u3001\u5f7c\u306f EDRF\u3001\u7279\u306b\u4f5c\u7528\u306e\u6027\u8cea\u3068\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u7814\u7a76\u3057\u3001EDRF \u304c\u5b9f\u969b\u306b\u306f\u5fc3\u81d3\u8840\u7ba1\u751f\u7406\u5b66<\/a><\/span>\u306b\u304a\u3051\u308b\u591a\u304f\u306e\u5074\u9762\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5316\u5408\u7269\u3067\u3042\u308b\u4e00\u9178\u5316\u7a92\u7d20<\/a><\/span>(NO) \u3067\u3042\u308b\u3053\u3068\u3092\u7a81\u304d\u6b62\u3081\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u306f<\/span>\u30d0\u30a4\u30a2\u30b0\u30e9\u306e\u85ac\u7406\u5b66\u7684\u958b\u767a<\/a><\/span>\u306b\u304a\u3044\u3066\u91cd\u8981\u3067\u3057\u305f\u3002<\/p>

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\u30d0\u30a4\u30a2\u30b0\u30e9\u306e\u72ec\u5360\u7279\u8a31\u306f 2011 \u5e74 6 \u6708\u9803\u306b\u53d6\u5f97\u3055\u308c\u3001\u305d\u308c\u4ee5\u964d\u306f\u5b8c\u5168\u306b<\/a><\/span>\u5408\u6cd5\u306a\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\u533b\u85ac\u54c1\u304c<\/a><\/span>\u306f\u308b\u304b\u306b\u5b89\u4fa1\u306b\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p><\/div>

\u53c2\u8003\u8cc7\u6599<\/h2>
  1. Sildenafil \u2013 afrikaans<\/a><\/li>
  2. \u0633\u064a\u0644\u062f\u064a\u0646\u0627\u0641\u064a\u0644 \u2013 arabe<\/a><\/li>
  3. \u0633\u064a\u0644\u062f\u0646\u0627\u0641\u064a\u0644 \u2013 arabe \u00e9gyptien<\/a><\/li>
  4. Sildenafilo \u2013 asturien<\/a><\/li>
  5. \u0633\u06cc\u0644\u062f\u0646\u0627\u0641\u06cc\u0644 \u2013 South Azerbaijani<\/a><\/li>
  6. Sildenaf\u0117ls \u2013 samogitien<\/a><\/li><\/ol><\/div>\n
    \n

    \n \u30b7\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u30fb\u95a2\u9023\u52d5\u753b\n <\/h2>\n
    \n \n
    \n
    \n