{"id":79129,"date":"2024-01-21T04:47:53","date_gmt":"2024-01-21T04:47:53","guid":{"rendered":"https:\/\/science-hub.click\/%E3%82%AB%E3%83%AB%E3%83%90%E3%83%9E%E3%82%BC%E3%83%94%E3%83%B3%E3%81%AB%E3%81%A4%E3%81%84%E3%81%A6%E8%A9%B3%E3%81%97%E3%81%8F%E8%A7%A3%E8%AA%AC\/"},"modified":"2024-01-21T04:47:53","modified_gmt":"2024-01-21T04:47:53","slug":"%E3%82%AB%E3%83%AB%E3%83%90%E3%83%9E%E3%82%BC%E3%83%94%E3%83%B3%E3%81%AB%E3%81%A4%E3%81%84%E3%81%A6%E8%A9%B3%E3%81%97%E3%81%8F%E8%A7%A3%E8%AA%AC","status":"publish","type":"post","link":"https:\/\/science-hub.click\/?p=79129","title":{"rendered":"\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac"},"content":{"rendered":"

\u5c0e\u5165<\/h2>
\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3<\/th><\/tr>
\n\"\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\"<\/figure>
\n\"\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\"<\/figure><\/td><\/tr>
\u4e00\u822c\u7684\u306a<\/th><\/tr>
IUPAC\u540d<\/td><\/tr>
CAS\u756a\u53f7<\/sup><\/td>298-46-4<\/span><\/span> 85756-57-6<\/span><\/span> (\u4e8c\u6c34\u548c\u7269)<\/td><\/tr>
ATC\u30b3\u30fc\u30c9<\/td>N03<\/span> AF01<\/span><\/span><\/td><\/tr>
\u30c9\u30e9\u30c3\u30b0\u30d0\u30f3\u30af<\/td>APRD00337<\/span><\/td><\/tr>
\u30d1\u30d6\u30b1\u30e0<\/td>2554<\/span><\/td><\/tr>
\u5316\u5b66\u7684\u6027\u8cea<\/th><\/tr>
\u751f\u306e\u30d5\u30a9\u30fc\u30df\u30e5\u30e9<\/td>C15H12N2O<\/sub>\u200b<\/sub>\u200b<\/sub><\/td><\/tr>
\u30e2\u30eb\u8cea\u91cf<\/a><\/span><\/td>236.2686 \u00b1 0.0135 g mol -1<\/sup><\/td><\/tr>
\u85ac\u7269\u52d5\u614b\u30c7\u30fc\u30bf<\/a><\/span><\/th><\/tr>
\u30d0\u30a4\u30aa\u30a2\u30d9\u30a4\u30e9\u30d3\u30ea\u30c6\u30a3<\/td>80%<\/td><\/tr>
\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7d50\u5408<\/td>76%<\/td><\/tr>
\u4ee3\u8b1d<\/a><\/span><\/td>CYP3A4 (\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3-10,11 \u30a8\u30dd\u30ad\u30b7\u30c9) \u306b\u3088\u308b\u809d\u81d3<\/td><\/tr>
\u9664\u53bb\u534a\u6e1b\u671f<\/a><\/span><\/td>25\uff5e65\u6642\u9593<\/a><\/span><\/td><\/tr>
\u6392\u6cc4<\/td>2\uff5e3%\u304c\u5909\u5316\u305b\u305a\u306b\u5c3f\u4e2d\u306b\u6392\u6cc4\u3055\u308c\u308b<\/td><\/tr>
\u6cbb\u7642\u4e0a\u306e\u8003\u616e\u4e8b\u9805<\/th><\/tr>
\u6295\u4e0e\u7d4c\u8def<\/td>\u30aa\u30fc\u30e9\u30eb<\/td><\/tr>
\u7279\u306b\u6307\u5b9a\u306e<\/a><\/span>\u306a\u3044\u9650\u308a\u3001SI \u304a\u3088\u3073 CNTP \u5358\u4f4d\u3002<\/center><\/td><\/tr><\/table>

\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3<\/b>\u306f\u3001\u3066\u3093\u304b\u3093\u306e\u6cbb\u7642\u3068\u6c17\u5206\u306e\u8abf\u6574\u306b\u4f7f\u7528\u3055\u308c\u308b\u85ac<\/a><\/span>\u3067\u3059\u3002<\/p>

\n\"\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\"<\/figure>

\u6b74\u53f2<\/h2>

\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\u306f\u30011953 \u5e74\u306b\u30b9\u30a4\u30b9\u306e\u30a6\u30a9\u30eb\u30bf\u30fc \u30b7\u30f3\u30c9\u30e9\u30fc<\/span>\u306b\u3088\u3063\u3066\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u3002<\/p>

\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\u306f\u30011962 \u5e74\u306b\u4e09\u53c9\u795e\u7d4c\u75db\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u521d\u3081\u3066\u5e02\u8ca9\u3055\u308c\u3001\u305d\u306e\u5f8c 1965 \u5e74\u306b\u82f1\u56fd\u3067\u30011974 \u5e74\u304b\u3089\u7c73\u56fd\u3067\u6297\u3051\u3044\u308c\u3093\u85ac\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002<\/p>

1971\u5e74\u3001\u7af9\u5d0e\u3068\u82b1\u5ca1\u306f\u3001\u6297\u7cbe\u795e\u75c5\u85ac\u306b\u62b5\u6297\u6027\u306e\u60a3\u8005\u306e\u8e81\u72b6\u614b\u3092\u6cbb\u7642\u3059\u308b\u305f\u3081\u306b\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\u3092\u4f7f\u7528\u3057\u305f\uff08\u5f53\u6642\u65e5\u672c\u3067\u306f\u30ea\u30c1\u30a6\u30e0\u306f<\/a><\/span>\u5165\u624b\u3067\u304d\u306a\u304b\u3063\u305f\uff09\u3002\u305d\u306e\u5f8c\u3001\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\u306f 1970 \u5e74\u4ee3\u306b\u53cc\u6975\u6027\u969c\u5bb3\u306b\u5bfe\u3057\u3066\u7814\u7a76\u3055\u308c\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>

\u9069\u5fdc\u75c7<\/h2>

\u90e8\u5206\u3066\u3093\u304b\u3093\u306f\u3001\u9854\u9762\u795e\u7d4c\u75db\u3068\u540c\u69d8\u306b\u3001\u3053\u306e\u6cbb\u7642\u306b\u3088\u304f\u53cd\u5fdc\u3057\u307e\u3059\u3002\u3053\u306e\u85ac\u306f\u7cbe\u795e\u533b\u5b66<\/a><\/span>\u3067\u3082\u6c17\u5206\u8abf\u6574\u85ac\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002<\/p>

\u653e\u5c04\u7dda\u7642\u6cd5<\/a><\/span>\u3092\u5408\u4f75\u3059\u308b\u795e\u7d4c\u7b4b\u7dca\u5f35\u75c7\u306f\u3001\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\u3067\u52b9\u679c\u7684\u306b\u6cbb\u7642\u3055\u308c\u307e\u3059\u3002<\/p>

\u4ee3\u8b1d<\/h2>

\u6442\u53d6\u5f8c\u3001\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\u306f\u6d88\u5316\u7ba1\u304b\u3089\u5438\u53ce\u3055\u308c\u307e\u3059<\/a><\/span>\u3002\u305d\u306e\u5f8c\u3001\u809d\u81d3\u3067\u30a2\u30a4\u30bd\u30b6\u30a4\u30e0 CYP3A4\u3001CYP2D\u3001CYP2C8 \u306b\u3088\u3063\u3066\u4ee3\u8b1d\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30a2\u30a4\u30bd\u30b6\u30a4\u30e0\u306f\u3001\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\u3092\u305d\u306e\u6d3b\u6027\u4ee3\u8b1d\u7269\u3067\u3042\u308b10,11 \u30a8\u30dd\u30ad\u30b7\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3<\/i>\u306b\u5909\u63db\u3059\u308b\u30b7\u30c8\u30af\u30ed\u30e0 p450 \u30b7\u30b9\u30c6\u30e0\u3092\u5f62\u6210\u3057\u307e\u3059\u3002<\/p>

\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\u306f\u3001\u591a\u304f\u306e\u85ac\u7269\u306e\u52b9\u679c\u3001\u3055\u3089\u306b\u306f\u305d\u308c\u81ea\u4f53\u306e\u4ee3\u8b1d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u9175\u7d20\u8a98\u5c0e\u5264<\/span>\u3067\u3059\u3002<\/p>

\u85ac\u7269\u306e\u8840\u6f3f\u6fc3\u5ea6\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u306f\u6709\u7528\u3067\u3042\u308a\u3001\u305d\u306e\u6709\u52b9\u6027\u306e\u6cbb\u7642<\/a><\/span>\u57df\u306f\u3001\u4f7f\u7528\u3055\u308c\u308b\u4ed6\u306e\u6cbb\u7642\u6cd5\u306b\u5fdc\u3058\u3066\u8840\u6db2<\/a><\/span>1 ml \u3042\u305f\u308a 4 \uff5e 12 \u03bcg \u3068\u63a8\u5b9a\u3055\u308c\u307e\u3059\u3002\u6b8b\u7559\u6fc3\u5ea6 (Cmin) \u306f\u3001\u514d\u75ab\u5b66\u7684\u65b9\u6cd5\u307e\u305f\u306f\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u6cd5 (\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u306f<\/a><\/span>\u6d3b\u6027\u30a8\u30dd\u30ad\u30b7\u4ee3\u8b1d\u7269\u3092\u6e2c\u5b9a\u3057\u307e\u3059) \u306b\u3088\u3063\u3066\u6c7a\u5b9a\u3055\u308c\u307e\u3059\u3002\u526f\u4f5c\u7528\u306f\u3001\u5358\u72ec\u7642\u6cd5\u3067\u306f Cmin \u304c 12 \u03bcg\/ml \u3092\u8d85\u3048\u3001\u4f75\u7528\u7642\u6cd5\u3067\u306f Cmin \u304c 8 \u03bcg\/ml \u3092\u8d85\u3048\u3066\u73fe\u308c\u307e\u3059\u3002\u30a8\u30dd\u30ad\u30b7\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\/\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\u306e\u6bd4\u7387\u306f\u3001\u5358\u72ec\u7642\u6cd5\u306e\u60a3\u8005\u3067\u306f 17%\u3001\u30d0\u30eb\u30d7\u30ed\u9178<\/a><\/span>\u3068\u4f75\u7528\u3057\u305f\u5834\u5408\u306f 30% \u3067\u3059\u3002<\/p>

\u4e09\u74b0\u7cfb\u5316\u5408\u7269\u306e\u514d\u75ab\u5b66\u7684\u691c\u51fa\u306f\u3001\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\u306e\u69cb\u9020\u3068\u306e\u4ea4\u5dee\u53cd\u5fdc\u306b\u3088\u3063\u3066\u640d\u306a\u308f\u308c\u307e\u3059\u3002<\/p>

\u85ac\u7269\u76f8\u4e92\u4f5c\u7528<\/span><\/h3>

\u30a8\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u3001\u30af\u30e9\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3<\/a><\/span>\u3001\u30c8\u30ed\u30a2\u30f3\u30c9\u30ed\u30de\u30a4\u30b7\u30f3<\/span>\u306a\u3069\u306e\u6297\u751f\u7269\u8cea\u306f\u3001\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\u306e\u8840\u6f3f\u6fc3\u5ea6\u3092\u5897\u52a0\u3055\u305b\u307e\u3059\u3002<\/p>

\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\u3068\u598a\u5a20<\/h2>

\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\u306f\u80ce\u76e4<\/a><\/span>\u3092\u901a\u904e\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u75c7\u4f8b\u306e 4 \uff5e 6% \u3067\u3001\u4e3b\u306b\u795e\u7d4c\u7ba1\u9589\u9396<\/a><\/span>\u7570\u5e38 (\u4e8c\u5206\u810a\u690e\u306a\u3069) \u3092\u4f34\u3046\u591a\u767a\u5947\u5f62\u75c7\u5019\u7fa4\u306e\u983b\u5ea6\u304c<\/a><\/span>\u5897\u52a0\u3057\u307e\u3059\u3002<\/p>

\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\u306f\u3001\u6cbb\u7642\u3092\u53d7\u3051\u305f\u6bcd\u89aa\u304b\u3089\u6bcd\u4e73\u3067\u80b2\u3066\u3089\u308c\u305f\u5b50\u4f9b\u306e\u8840\u6db2\u4e2d\u306b\u691c\u51fa\u3055\u308c\u3001\u3053\u308c\u3089\u306e\u5b50\u4f9b\u306b\u304a\u3051\u308b\u85ac\u7269\u6027\u809d\u708e<\/a><\/span>\u306e\u539f\u56e0\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p><\/div>

\u53c2\u8003\u8cc7\u6599<\/h2>
  1. \u0643\u0627\u0631\u0628\u0627\u0645\u0627\u0632\u064a\u0628\u064a\u0646 \u2013 arabe<\/a><\/li>
  2. Carbamazepina \u2013 catalan<\/a><\/li>
  3. Carbamasepin \u2013 gallois<\/a><\/li>
  4. Carbamazepin \u2013 allemand<\/a><\/li>
  5. \u039a\u03b1\u03c1\u03b2\u03b1\u03bc\u03b1\u03b6\u03b5\u03c0\u03af\u03bd\u03b7 \u2013 grec<\/a><\/li>
  6. Carbamazepine \u2013 anglais<\/a><\/li><\/ol><\/div>\n
    \n

    \n \u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u30fb\u95a2\u9023\u52d5\u753b\n <\/h2>\n
    \n \n
    \n
    \n