{"id":86901,"date":"2024-03-22T22:46:36","date_gmt":"2024-03-22T22:46:36","guid":{"rendered":"https:\/\/science-hub.click\/%E8%BB%A2%E5%86%99%E5%BE%8C%E4%BF%AE%E9%A3%BE-%E5%AE%9A%E7%BE%A9\/"},"modified":"2024-03-22T22:46:36","modified_gmt":"2024-03-22T22:46:36","slug":"%E8%BB%A2%E5%86%99%E5%BE%8C%E4%BF%AE%E9%A3%BE-%E5%AE%9A%E7%BE%A9","status":"publish","type":"post","link":"https:\/\/science-hub.click\/?p=86901","title":{"rendered":"\u8ee2\u5199\u5f8c\u4fee\u98fe – \u5b9a\u7fa9"},"content":{"rendered":"

\u5c0e\u5165<\/h2>

\u8ee2\u5199\u5f8c\u4fee\u98fe\u306f\u3001<\/b> RNA \u304c\u8ee2\u5199\u5f8c\u306b\u53d7\u3051\u308b\u3059\u3079\u3066\u306e\u4fee\u98fe\u3092\u8868\u3057\u307e\u3059\u3002\u3053\u308c\u306fRNA \u6210\u719f<\/b>\u3068\u3082\u547c\u3070\u308c\u307e\u3059\u3002\u6700\u3082\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u308b\u4fee\u98fe\u306f\u3001\u30ad\u30e3\u30c3\u30d7\u306e\u8ffd\u52a0\u3001\u30dd\u30ea\u30a2\u30c7\u30cb\u30eb\u5316<\/a><\/span>\u3001\u3055\u3089\u306b\u306f\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3067\u3059\u304c\u3001\u4ed6\u306b\u3082\u591a\u304f\u306e\u4fee\u98fe\u304c\u3042\u308a\u307e\u3059\u3002<\/p>

\u5b9a\u7fa9\u3068\u5f79\u5272<\/h2>

RNA \u306e\u8ee2\u5199\u5f8c\u4fee\u98fe\u306f<\/a><\/span>\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5236\u5fa1<\/span>\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u30b9\u30c6\u30c3\u30d7\u3067\u3042\u308a\u3001\u3055\u307e\u3056\u307e\u306a\u4fee\u98fe\u304c\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u8ee2\u5199\u5f8c\u5236\u5fa1<\/a><\/span>\u306e\u8981\u7d20\u3067\u3042\u308b\u3068\u4e00\u822c\u306b\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u3055\u307e\u3056\u307e\u306a\u4fee\u98fe\u306f\u3001RNA \u306e\u5b89\u5b9a\u6027\u3001\u7ffb\u8a33\u80fd\u529b\u3001\u3055\u3089\u306b\u306f\u7ffb\u8a33\u3055\u308c\u308b\u914d\u5217\u306e\u4fee\u98fe\u306a\u3069\u3001RNA \u306e\u3055\u307e\u3056\u307e\u306a\u7279\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>

\u307b\u3068\u3093\u3069\u306e RNA \u306f\u8ee2\u5199\u5f8c\u306b\u4fee\u98fe\u3055\u308c\u307e\u3059\u304c\u3001\u4fee\u98fe\u3055\u308c\u305f RNA \u3068\u4fee\u98fe\u306e\u6027\u8cea\u306f\u539f\u6838\u751f\u7269<\/a><\/span>\u3068\u771f\u6838\u751f\u7269\u306e\u9593\u3001\u304a\u3088\u3073\u771f\u6838\u751f\u7269\u306e\u6838\u3068\u7d30\u80de\u5c0f\u5668\u5b98\u306e\u9593\u3067\u7570\u306a\u308a\u307e\u3059\u3002<\/p>

\u8ee2\u5199\u5f8c\u4fee\u98fe<\/h2>

\u30bb\u30b0\u30e1\u30f3\u30c6\u30fc\u30b7\u30e7\u30f3<\/a><\/span><\/span><\/h3>

\u7aef\u306e\u7de8\u96c6<\/span><\/h3>

5’\u30ad\u30e3\u30c3\u30d7\u306e\u8ffd\u52a0<\/span><\/h4>

\u771f\u6838\u751f\u7269\u3067\u306f\u3001\u7279\u5b9a\u306e RNA\u3001\u7279\u306b\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fc RNA \u306f 5′ \u672b\u7aef\u306e\u4fee\u98fe\u3092\u53d7\u3051\u3001\u30a8\u30ad\u30bd\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u306b\u3088\u308b\u5206\u89e3\u304b\u3089\u4fdd\u8b77\u3055\u308c\u307e\u3059\u3002\u30ad\u30e3\u30c3\u30d7\u3068\u547c\u3070\u308c\u308b\u3053\u306e\u4fee\u98fe\u306f\u30015′-5′ \u4e8c\u30ea\u30f3\u9178\u200b\u200b\u7d50\u5408\u3092\u4ecb\u3057\u3066 RNA \u306e\u6700\u521d\u306e\u30cc\u30af\u30ec\u30aa\u30c1\u30c9<\/a><\/span>\u306b 7-\u30e1\u30c1\u30eb\u30b0\u30a2\u30ce\u30b7\u30f3\u3092\u4ed8\u52a0\u3059\u308b<\/a><\/span>\u3053\u3068\u3067\u69cb\u6210\u3055\u308c\u307e\u3059\u3002\u8ee2\u5199\u3055\u308c\u305f RNA \u306e\u6700\u521d\u306e 2 \u3064\u306e\u30ea\u30dc\u30fc\u30b9\u3082\u30012′ \u4f4d\u3067\u30e1\u30c1\u30eb\u5316\u3092\u53d7\u3051\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>

\n\"\"<\/figure>
\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA\u306e5’\u672b\u7aef\u306e\u30ad\u30e3\u30c3\u30d7\u306e\u69cb\u9020<\/div><\/div><\/div><\/div>

\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA\u306e\u5834\u5408\u3001\u3053\u306e\u30ad\u30e3\u30c3\u30d7\u306f\u3001\u7279\u306b\u958b\u59cb\u56e0\u5b50eIF4E\u3092\u542b\u3080\u7279\u5b9a\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u306b\u3088\u3063\u3066\u8a8d\u8b58\u3055\u308c\u3001\u7279\u306b\u30ea\u30dc\u30bd\u30fc\u30e0<\/a><\/span>\u306e\u52d5\u54e1\u3068\u30bf\u30f3\u30d1\u30af\u8cea<\/a><\/span>\u3078\u306e\u7ffb\u8a33\u3092\u53ef\u80fd\u306b\u3057\u307e\u3059\u3002<\/p>

3’\u30dd\u30ea\u30a2\u30c7\u30cb\u30eb\u5316<\/span><\/h4>

pre-mRNA \u306f\u3001\u6700\u521d\u306b\u6838\u5185\u306e\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u30dd\u30ea\u30a2\u30c7\u30cb\u30eb\u5316\u90e8\u4f4d (AAUAAA) \u3067\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u306b\u3088\u3063\u3066\u5207\u65ad\u3055\u308c\u307e\u3059\u3002\u6b21\u306b\u3001\u5207\u65ad\u306e\u4e0a\u6d41\u306e\u5207\u65ad<\/a><\/span>\u7523\u7269\u306b\u7d04 200 \u500b\u306e\u30a2\u30c7\u30ce\u30b7\u30f3<\/a><\/span>\u6b8b\u57fa (A) \u3092\u4ed8\u52a0\u3059\u308b\u30dd\u30ea\u30a2\u30c7\u30cb\u30eb\u5316\u53cd\u5fdc\u304c\u8d77\u3053\u308a\u3001\u4e0b\u6d41\u306e\u65ad\u7247\u306f\u6025\u901f\u306b\u5206\u89e3\u3055\u308c\u307e\u3059\u3002<\/p>

\u30ad\u30e3\u30c3\u30d7\u3068\u540c\u69d8\u306b\u3001PAB (PolyA Binding Protein) \u3092\u542b\u3080\u8a8d\u8b58\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u304c\u3042\u308a\u307e\u3059\u3002<\/p>

\u5869\u57fa\u914d\u5217\u3092\u5909\u3048\u308b<\/span><\/h3>

\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0<\/span><\/h4>

\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306f\u3001RNA \u306e 1 \u3064\u4ee5\u4e0a\u306e\u914d\u5217 (\u30a4\u30f3\u30c8\u30ed\u30f3) \u306e\u5207\u9664<\/a><\/span>(\u30b7\u30b9 \u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0)\u3001\u307e\u305f\u306f\u305d\u306e\u5f8c\u5207\u9664\u3055\u308c\u308b\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u7d50\u5408\u70b9<\/a><\/span>\u3067\u518d\u5f62\u6210\u3059\u308b 2 \u3064\u306e\u7570\u306a\u308b RNA \u306e\u7e2b\u5408\u306e\u3044\u305a\u308c\u304b\u3067\u69cb\u6210\u3055\u308c\u307e\u3059\u3002<\/p>

\u7248<\/span><\/h4>

RNA \u7de8\u96c6\u306f\u3001RNA \u914d\u5217\u306e\u5909\u66f4\u306b\u3064\u306a\u304c\u308b\u3055\u307e\u3056\u307e\u306a\u30d7\u30ed\u30bb\u30b9\u3092\u30ab\u30d0\u30fc\u3059\u308b\u7528\u8a9e\u3067\u3059\u3002<\/p>

\u5316\u5b66\u4fee\u98fe<\/span><\/h3>

\u30e1\u30c1\u30eb\u5316<\/span><\/h4>
\n\"\"<\/figure>
\u30b7\u30c8\u30b7\u30f3<\/a><\/span>\u4e0a\u306b\u30e1\u30c1\u30eb\u5316\u90e8\u4f4d\u304c\u89b3\u5bdf\u3055\u308c\u308b\u3002\u5f97\u3089\u308c\u305f\u30e1\u30c1\u30eb\u5316\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u540d\u524d\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/div><\/div><\/div>

\u30e1\u30c1\u30eb\u5316\u306f\u3001\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u6700\u3082\u983b\u7e41\u306b\u8d77\u3053\u308b\u8ee2\u5199\u5f8c\u4fee\u98fe\u306e 1 \u3064\u3067\u3059\u3002\u30e1\u30c1\u30eb\u5316\u306b\u306f\u4e3b\u306b 2 \u3064\u306e\u30af\u30e9\u30b9\u304c\u3042\u308a\u307e\u3059\u3002<\/p>