{"id":99231,"date":"2024-03-23T13:11:14","date_gmt":"2024-03-23T13:11:14","guid":{"rendered":"https:\/\/science-hub.click\/%E3%82%B3%E3%82%A8%E3%83%B3%E3%82%B6%E3%82%A4%E3%83%A0A%E3%81%AB%E3%81%A4%E3%81%84%E3%81%A6%E8%A9%B3%E3%81%97%E3%81%8F%E8%A7%A3%E8%AA%AC\/"},"modified":"2024-03-23T13:11:14","modified_gmt":"2024-03-23T13:11:14","slug":"%E3%82%B3%E3%82%A8%E3%83%B3%E3%82%B6%E3%82%A4%E3%83%A0A%E3%81%AB%E3%81%A4%E3%81%84%E3%81%A6%E8%A9%B3%E3%81%97%E3%81%8F%E8%A7%A3%E8%AA%AC","status":"publish","type":"post","link":"https:\/\/science-hub.click\/?p=99231","title":{"rendered":"\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0A\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac"},"content":{"rendered":"

\u5c0e\u5165<\/h2>
\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0A<\/th><\/tr>
\n\"\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0A\"<\/figure><\/td><\/tr>
\u4e00\u822c\u7684\u306a<\/th><\/tr>
IUPAC\u540d<\/td><\/tr>
\u540c\u7fa9\u8a9e<\/td>CoA \u307e\u305f\u306f CoA-SH<\/td><\/tr>
CAS\u756a\u53f7<\/sup><\/td>85-61-0<\/span><\/span><\/td><\/tr>
No.EINECS<\/sup><\/td> 201-619-0<\/span><\/td><\/tr>
\u30c9\u30e9\u30c3\u30b0\u30d0\u30f3\u30af<\/td>DB01992<\/span><\/td><\/tr>
\u30d1\u30d6\u30b1\u30e0<\/td>6816<\/span> 3312<\/span><\/td><\/tr>
\u7b11\u9854<\/td><\/tr>
\u30a4\u30f3\u30c1\u30c1<\/td><\/tr>
\u5316\u5b66\u7684\u6027\u8cea<\/th><\/tr>
\u751f\u306e\u30d5\u30a9\u30fc\u30df\u30e5\u30e9<\/td>C 21<\/sub> H 36<\/sub> N 7<\/sub> W 16<\/sub> P 3<\/sub> S<\/td><\/tr>
\u30e2\u30eb\u8cea\u91cf<\/a><\/span><\/td>767.534 \u00b1 0.031 g mol -1<\/sup><\/td><\/tr>
\u751f\u614b\u6bd2\u6027\u5b66<\/th><\/tr>
\u30ed\u30b0P<\/td> -5,340<\/td><\/tr>
\u7279\u306b\u6307\u5b9a\u306e<\/a><\/span>\u306a\u3044\u9650\u308a\u3001SI \u304a\u3088\u3073 CNTP \u5358\u4f4d\u3002<\/center><\/td><\/tr><\/table>

\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0 A<\/b> (CoA) \u306f\u3001\u591a\u304f\u306e\u4ee3\u8b1d<\/a><\/span>\u7d4c\u8def (\u30af\u30ec\u30d6\u30b9\u56de\u8def\u3001\u30d9\u30fc\u30bf\u9178\u5316) \u306b\u95a2\u4e0e\u3059\u308b\u30a2\u30b7\u30eb\u57fa\u8ee2\u79fb\u88dc\u9175\u7d20<\/a><\/span>\u3067\u3059\u3002<\/p>

\u3053\u308c\u306f\u30011951 \u5e74\u306b\u30c9\u30a4\u30c4\u306e\u751f\u5316\u5b66\u8005\u30d5\u30e7\u30fc\u30c9\u30eb \u30e9\u30a4\u30cd\u30f3 (1964 \u5e74\u306b\u30ce\u30fc\u30d9\u30eb\u8cde\u3092\u53d7\u8cde) \u306b\u3088\u3063\u3066\u3001\u9175\u6bcd<\/a><\/span>\u7d30\u80de\u304b\u3089\u30a2\u30bb\u30c1\u30eb\u88dc\u9175\u7d20 A (\u300c\u6d3b\u6027\u5316\u9162\u9178\u300d) \u306e\u5f62\u3067\u521d\u3081\u3066\u5358\u96e2\u3055\u308c\u307e\u3057\u305f\u3002<\/p>

\n\"\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0A\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\"<\/figure>

\u69cb\u9020<\/h2>

\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0 A \u306f\u3001\u30cc\u30af\u30ec\u30aa\u30c1\u30c9<\/a><\/span>\u3001\u30a2\u30c7\u30ce\u30b7\u30f3<\/a><\/span>\u4e8c\u30ea\u30f3\u9178 (ADP)\u3001\u30d3\u30bf\u30df\u30f3<\/a><\/span>\u3001\u30d3\u30bf\u30df\u30f3 B5<\/a><\/span> (\u30d1\u30f3\u30c8\u30c6\u30f3\u9178)\u3001\u304a\u3088\u3073\u30a2\u30df\u30ce\u9178<\/a><\/span>\u3067<\/a><\/span>\u3042\u308b\u30b7\u30b9\u30c6\u30a4\u30f3\u306e\u7570\u306a\u308b\u8981\u7d20\u3067\u69cb\u6210\u3055\u308c\u3066\u304a\u308a\u3001\u308f\u305a\u304b\u306b\u4fee\u98fe\u3055\u308c\u3066\u7d50\u5408\u3057\u3066\u3044\u307e\u3059\u3002<\/p>

\n\"\"<\/figure>
\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0A\u306e\u69cb\u9020<\/div><\/div><\/div>

\u8a73\u7d30\u306b\u306f\u3001\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0 A \u306f\u6b21\u306e\u3082\u306e\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>

  1. \u30a2\u30c7\u30ce\u30b7\u30f33′\u30ea\u30f3\u9178<\/a><\/span><\/li>
  2. \u4e8c\u30ea\u30f3\u9178\u5869<\/li>
  3. \u30d1\u30f3\u30c8\u9178<\/a><\/span>(3 + 4 = \u30d1\u30f3\u30c8\u30c6\u30f3\u9178)<\/li>
  4. \u03b2-\u30a2\u30e9\u30cb\u30f3<\/li>
  5. \u30b7\u30b9\u30c6\u30a2\u30df\u30f3\uff082-\u30a2\u30df\u30ce\u30a8\u30bf\u30f3\u30c1\u30aa\u30fc\u30eb\uff09<\/li><\/ol>

    \u305d\u306e\u53cd\u5fdc\u90e8\u5206\u306f\u30c1\u30aa\u30a8\u30bf\u30ce\u30fc\u30eb\u30a2\u30df\u30f3\u306e\u30c1\u30aa\u30fc\u30eb\u5b98\u80fd\u57fa (-SH) (\u56f3 1) \u3067\u3042\u308a\u3001HS-CoA (\u307e\u305f\u306f CoA-SH) \u3067\u8868\u3055\u308c\u308b\u3053\u3068\u304c\u3088\u304f\u3042\u308a\u307e\u3059\u3002<\/p>

    \u30ab\u30eb\u30dc\u30f3\u9178\u3068\u306e\u53cd\u5fdc\u6027<\/h2>

    \u30b7\u30b9\u30c6\u30a2\u30df\u30f3\u306e\u30c1\u30aa\u30fc\u30eb\u6a5f\u80fd\u306e\u304a\u304b\u3052\u3067\u3001\u88dc\u9175\u7d20 A \u306f\u3001\u7279\u5b9a\u306e\u5316\u5408\u7269 (\u8102\u80aa\u9178\u306a\u3069) \u306e\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u5b98\u80fd\u57fa\u3068\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb CoA \u3068\u547c\u3070\u308c\u308b\u30c1\u30aa\u30a8\u30b9\u30c6\u30eb\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3053\u306e\u30c1\u30aa\u30a8\u30b9\u30c6\u30eb\u7d50\u5408\u306f\u7279\u306b\u30a8\u30cd\u30eb\u30ae\u30fc<\/a><\/span>\u304c\u8c4a\u5bcc\u3067\u3059\u3002<\/p>

    CoA-SH + R-COOH \u21d2 CoA-S-CO-R ( + H 2<\/sub> O )<\/p>

    \u3057\u305f\u304c\u3063\u3066\u3001\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0 A \u306f\u8102\u80aa\u306e\u4ee3\u8b1d\u306b\u76f4\u63a5 (\u30a2\u30b7\u30eb CoA \u3068\u3057\u3066) \u95a2\u4e0e\u3057\u3001\u70ad\u6c34\u5316\u7269\u304a\u3088\u3073\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4ee3\u8b1d\u306b\u306f\u9593\u63a5\u7684\u306b (\u30a2\u30bb\u30c1\u30eb CoA \u3068\u3057\u3066) \u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>

    \u30b3\u30a8\u30f3\u30b6\u30a4\u30e0A\u306f\u3001\u30d1\u30fc\u30c8\u30ca\u30fc\u3068\u5f62\u6210\u3059\u308b\u9ad8\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u30c1\u30aa\u30a8\u30b9\u30c6\u30eb\u7d50\u5408\u3092\u4ecb\u3057\u3066\u30d1\u30fc\u30c8\u30ca\u30fc\u3092\u300c\u6d3b\u6027\u5316\u300d\u3057\u3001\u88dc\u9175\u7d20\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u306a\u3051\u308c\u3070\u53c2\u52a0\u3057\u306a\u3044\u3067\u3042\u308d\u3046\u53cd\u5fdc\u306b\u53c2\u52a0\u3067\u304d\u308b\u3088\u3046\u306b\u3059\u308b\u3068\u3044\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>

    \u751f\u5408\u6210<\/h2>

    \u30b3\u30a8\u30f3\u30b6\u30a4\u30e0A\u306f\u3001\u30d1\u30f3\u30c8\u30c6\u30f3\u9178\uff08\u30d3\u30bf\u30df\u30f3B5\uff09\u306e\u5171\u5f79\u5869\u57fa\u3067\u3042\u308b\u30d1\u30f3\u30c8\u30c6\u30cd\u30fc\u30c8\u304b\u30895\u6bb5\u968e\u3067\u5408\u6210\u3055\u308c\u307e\u3059\u3002<\/p>

    1. \u30d1\u30f3\u30c8\u30c6\u30cd\u30fc\u30c8\u306f\u3001\u9175\u7d20<\/a><\/span>\u30d1\u30f3\u30c8\u30c6\u30cd\u30fc\u30c8\u30ad\u30ca\u30fc\u30bc (PanK\u3001CoaA\u3001CoaX) \u306b\u3088\u3063\u3066 4′-\u30db\u30b9\u30db\u30d1\u30f3\u30c8\u30c6\u30cd\u30fc\u30c8\u306b\u30ea\u30f3\u9178\u5316\u3055\u308c\u307e\u3059\u3002<\/li>
    2. \u9175\u7d20\u30db\u30b9\u30db\u30d1\u30f3\u30c8\u30c6\u30ce\u30a4\u30eb\u30b7\u30b9\u30c6\u30a4\u30f3\u5408\u6210<\/span>\u9175\u7d20 (CoaB) \u306b\u3088\u3063\u3066\u30b7\u30b9\u30c6\u30a4\u30f3\u5206\u5b50<\/a><\/span>\u304c 4′-\u30db\u30b9\u30db\u30d1\u30f3\u30c8\u30c6\u30cd\u30fc\u30c8\u306b\u4ed8\u52a0\u3055\u308c\u3066\u30014′-\u30db\u30b9\u30db-N-\u30d1\u30f3\u30c8\u30c6\u30ce\u30a4\u30eb\u30b7\u30b9\u30c6\u30a4\u30f3 (PPC) \u304c\u5f62\u6210\u3055\u308c\u307e\u3059\u3002<\/li>
    3. PPC\u306f\u3001\u9175\u7d20\u30db\u30b9\u30db\u30d1\u30f3\u30c8\u30c6\u30ce\u30a4\u30eb\u30b7\u30b9\u30c6\u30a4\u30f3\u30c7\u30ab\u30eb\u30dc\u30ad\u30b7\u30e9\u30fc\u30bc\uff08PPC-DC\u3001CoaC\uff09\u306e\u4f5c\u7528\u306b\u3088\u308a4′-\u30db\u30b9\u30db\u30d1\u30f3\u30c6\u30c6\u30a4\u30f3\u306b\u8131\u70ad\u9178\u3055\u308c\u307e\u3059\u3002<\/li>
    4. 4′-\u30db\u30b9\u30db\u30d1\u30f3\u30c6\u30c6\u30a4\u30f3\u306f\u3001 \u9175\u7d20\u30db\u30b9\u30db\u30d1\u30f3\u30c6\u30c6\u30a4\u30f3 \u30a2\u30c7\u30cb\u30ea\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc<\/a><\/span><\/span>(CoaD) \u306e\u4f5c\u7528\u306b\u3088\u308a\u30a2\u30c7\u30cb\u30ea\u30eb\u5316\u3055\u308c (\u30a2\u30c7\u30ce\u30b7\u30f3\u4e00\u30ea\u30f3\u9178\u306e\u4ed8\u52a0)\u3001\u30c7\u30db\u30b9\u30db CoA \u3092\u5f62\u6210\u3057\u307e\u3059\u3002<\/li>
    5. \u8131\u30ea\u30f3\u9178-CoA \u306f\u3001\u9175\u7d20\u8131\u30ea\u30f3\u9178\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0 A \u30ad\u30ca\u30fc\u30bc<\/span>(CoaE) \u306e\u4f5c\u7528\u306b\u3088\u308b ATP \u3068\u306e\u53cd\u5fdc\u306b\u3088\u308a\u3001\u6700\u7d42\u7684\u306b\u30ea\u30f3\u9178\u5316\u3055\u308c\u3066\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0 A \u306b\u306a\u308a\u307e\u3059\u3002<\/li><\/ol>

      CoA \u30bd\u30fc\u30b9<\/h2>

      \u30db\u30eb\u30e2\u30f3\u3001\u30ad\u30ce\u30b3\u3001\u8089\u3001\u5375\u9ec4<\/a><\/span>\u3002<\/p><\/div>

      \u53c2\u8003\u8cc7\u6599<\/h2>
      1. \u0645\u0631\u0627\u0641\u0642 \u0627\u0644\u0625\u0646\u0632\u064a\u0645-\u0623 \u2013 arabe<\/a><\/li>
      2. \u06a9\u0648\u0622\u0646\u0632\u06cc\u0648\u0645 \u0622 \u2013 South Azerbaijani<\/a><\/li>
      3. Koenzim A \u2013 bosniaque<\/a><\/li>
      4. Coenzim A \u2013 catalan<\/a><\/li>
      5. Koenzym A \u2013 tch\u00e8que<\/a><\/li>
      6. Coenzym A \u2013 allemand<\/a><\/li><\/ol><\/div>\n
        \n

        \n \u30b3\u30a8\u30f3\u30b6\u30a4\u30e0A\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u30fb\u95a2\u9023\u52d5\u753b\n <\/h2>\n
        \n \n
        \n
        \n